The ongoing debate about the FDA approval of BiDil in 2005 demonstrates how the first racially/ethnically licensed drug is entangled in both Utopian and dystopian future visions about the continued saliency of race/ethnicity in science and medicine. Drawing on the sociology of expectations, this paper analyzes how scientists in the field of pharmacogenetics are constructing certain visions of the future with respect to the use of social categories of race/ethnicity and the impact of high-throughput genotyping technologies that promise to transform (...) scientific practices. (shrink)

In a recent discussion about how scientific knowledge might potentially change our understanding of the nature and extent of human genetic, cultural, or biological variation, the sociologist David Skinner identified two competing visions of the future: one that was decidedly dystopian, which conjured up a “re-racialized” future, and an opposing utopian future in which the potential for racialized thinking might be finally overcome. We can situate the ongoing debates about the congestive heart failure drug BiDil, approved by the Food and (...) Drug Administration for use only by African Americans, in relation to these differing future prospects.When the FDA announced its approval of BiDil in June 2005, it located the drug, and perhaps the future of pharmaceutical development, within a particular vision of the future, heralding BiDil as “representing a step toward the promise of personalized medicine.” The discourse of “personalized medicine” can be characterized as part of a utopian future, one in which clinicians will be able to make increasingly individualized decisions based on each patient’s genetic makeup so that the drugs they take will be those that work best for them. (shrink)

Herbert Marcuse examined the subjective and material conditions of radical social change and developed the "Great Refusal," a radical concept of "the protest against that which is." The editors and contributors to the exciting new volume The Great Refusal provide an analysis of contemporary social movements around the world with particular reference to Marcuse's revolutionary concept. The book also engages-and puts Marcuse in critical dialogue with-major theorists including Slavoj Žižek and Michel Foucault, among others. The chapters in this book analyze (...) different elements and locations of the contemporary wave of struggle, drawing on the work and vision of Marcuse in order to reveal, with a historical perspective, the present moment of resistance. Essays seek to understand recent uprisings-such as the Zapatistas in Mexico, the Arab Spring, and the Occupy movement-in the context of Marcuse's powerful conceptual apparatus. The Great Refusal also charts contemporary social movements against global warming, mass incarceration, police brutality, white supremacy, militarization, technological development, and more, to provide insights that advance our understanding of resistance today. Contributors include: Kevin B. Anderson, Stanley Aronowitz, Joan Braune, Jenny Chan, Angela Y. Davis, Arnold L. Farr, Andrew Feenberg, Michael Forman, Christian Fuchs, Stefan Gandler, Christian Garland, Toorjo Ghose, Imaculada Kangussu, George Katsiaficas, Douglas Kellner, Sarah Lynn Kleeb, Filip Kovacevic, Lauren Langman, Heather Love, Peter Marcuse, Martin J. Beck Matuštík, Russell Rockwell, AK Thompson, Marcelo Vieta, and the editors. (shrink)

We show that there exists a real α such that, for all reals β, if α is linear reducible to β then β≤Tα. In fact, every random real satisfies this quasi-maximality property. As a corollary we may conclude that there exists no ℓ-complete Δ2 real. Upon realizing that quasi-maximality does not characterize the random reals–there exist reals which are not random but which are of quasi-maximal ℓ-degree–it is then natural to ask whether maximality could provide such a characterization. Such hopes, (...) however, are in vain since no real is of maximal ℓ-degree. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

This book celebrates the work of Patricia Werhane, an iconic figure in business ethics. This festschrift is a collection of articles that build on Werhane’s contributions to business ethics in such areas as Employee Rights, the Legacy of Adam Smith, Moral Imagination, Women in Business, the development of the field of business ethics, and her contributions to such fields as Health Care, Education, Teaching, and Philosophy. All papers are new contributions to the management literature written by well-known business ethicists, such (...) as Norman Bowie, Richard De George, Ronald Duska, Edwin Hartman, Michael Hoffman, Mollie Painter-Morland, Mark Schwartz, Andrew Wicks, and others. The volume is comprised of articles that reflect on Werhane’s work as well as build on it as a way to advance further research. At the end of the festschrift, Pat Werhane provides responses to each chapter. The first chapter of the book also includes the overview of Patricia Werhane’s work and her academic career. The book is written to appeal to management scholars and graduate students interested in the areas of Business Ethics, Modern Capitalism, and Human Rights. Patricia Werhane is one of the most distinguished figures in the field of business ethics. She was a founder of the field, she is one of its leading scholars, and she has had a profound impact on the world of business practice. Among her many accomplishments, Pat is known for her original work on moral imagination, she is an acclaimed authority on employee rights in the workplace, and she is one of the leading scholars on Adam Smith. Having been active in Academia for over 50 years, Werhane is a prolific author of over a hundred articles and book chapters, and the author or editor of twenty-seven books, including Adam Smith and his Legacy for Modern Capitalism, Moral Imagination and Management Decision-Making, and co-authored books Organization Ethics in Health Care, Alleviating Poverty Through Profitable Partnerships, Obstacles to Ethical Decision-Making, Corporate Responsibility: The American Experience, and Research Approaches to Business Ethics and Corporate Responsibility. (shrink)

Like _Beyond All Appearances_,_ _which it supplements, Paul Weiss’s new book is a fundamental work which faces all the hard issues which are not only at the heart of philosophy but at the core of our entire culture. Readers of Mr. Weiss’s phenomenology of religion will need no introduction to this new work which expands and clari­fies many of the issues raised in _Beyond All Appearances. _However, no knowl­edge of Paul Weiss’s previous books is required to understand and appreciate this (...) brilliant new exposition. Weiss’s plain style makes his ideas accessible to all intelligent readers, whether or not they have been trained as professional philosophers. Here in _First Considerations _Mr. Weiss addresses himself to such topics as actuality, internalization, evidence, names, substance, being, natures and possibilities, existence, unity and the cosmos—issues which have engrossed him as a moral philosopher and meta­physician throughout his distinguished career. In his progress through the ideas and issues expounded in this new book Mr. Weiss is concerned with the human condition distinctive of this species of ours. Rigorously applied, his moral philosophy is as complete and thorough as that of any of the major thinkers, and provides as complete a guide as, for example, that of Buddhism. A highly original work, no doubt well in advance of current trends in philosophy, _First Considerations _will provoke further thought and discussion and will be regarded as a seminal work in modern philosophical approaches. (shrink)

In lieu of an abstract, here is a brief excerpt of the content: Six Poems GEORGE KALOGERIS The Atomists To see what the matter is, in all of its dense, Teeming particulars, and not through the lens Of a microscope but by the most lucid, precise, Leap of imagination: the first was Leucíppus. But it was his student, Democritus, who stated That human understanding was truly futile, Given the random collisions of atoms. Still, He blinded himself to keep from (...) being distracted. When he broke the long-jump record by two whole feet, Bob Beamon dropped to his knees, buried his face In his hands, and wept in a pit of sand—the trace Of his human, Olympian flight still fresh as a heel-print. When the earthquake struck Kalamáta, and Uncle Sotíri Lost everything, he asked a taxi driver To take him to “a nice high place by the sea. And then come back for me in half an hour.” arion 28.3 winter 2021 58 six poems One Credit Seminar on the Odes of Horace We were sitting around a polished oak table, just getting to Those famous lines near the end of the Sestius Ode: Revenant whitefaced Death is walking not knowing whether He’s going to knock at a rich man’s door or a poor man’s When one of the students (Andrew) said it was “totally weird”— Which led us to look at the paleness of Death’s appearance, Whose pallor is what, when he comes, comes with him: the sickness and shock In his ghastly face. And that’s where we stopped. And then It was Jennifer’s email, saying “I’m sorry for missing class, But I’m having panic attacks. I keep flashing back To March 19th, when I entered my dorm-room and found my boyfriend Dead of an overdose... I can get you a note... What reading should I do to be prepared for next week?” O goodlooking fortunate Sestius, don’t put your hope in the future; The night is falling, the shades are gathering around; The walls of Pluto’s shadowy house are closing you in. There who will be lord of the feast? What will it matter, What will it matter there, whether you fell in love With Lycidas, this or that girl with him, or he With her? So David Ferry’s great translation goes, And its tone of tender, knowing, bemusement is Horace’s Pitying voice, but whose pity has come to speak to us Through the whitefaced mouth of revenant Death, still going From house to house, until he gets to Jennifer’s dorm-room. And what will it matter now if Andrew was drawn to the line About fishermen hauling their caulked boats to the water? It’s late September. We’re sitting around a polished oak table Whose wood is sacred to Jove, whose lightning-bolt Has already sounded deep in the heart of Indian summer. George Kalogeris 59 Greek School The very first poem I ever knew by heart: That sing-song forsaken one assigned to me. Recited on our other Independence Day. When some of the girls were dressed in peasant costumes, And some of the boys in kilts of the freedom fighters. And the timid rest of us in our Sunday best. In the church gym, where Father Mihos called us Up to the microphone, and one by one We showed the parents what we’d learned in Greek school. In Horace’s Ode to his Lyre, the poet prays That his song will serve as the medicine of sorrows, His stricken voice the trembling instrument— Schooled as he was in Sappho, who said the ancient Prescription left a bittersweet taste in her mouth: Glukopikron. For me it’s that first-grade poem I stammer to remember: Egwo tha geino Yiatrós... “I shall grow up to be a doctor...” Just saying that, my elders perk up their ears. And even if Poetry wasn’t the kind of calling Expected of me, and one by one they all Got sick and died, it’s still the medicine That keeps them leaning forward on their folding chairs. 60 six poems Money Doesn’t Grow On Trees But evergreen the... (shrink)

We say that A≤LRB if every B-random set is A-random with respect to Martin–Löf randomness. We study this relation and its interactions with Turing reducibility, classes, hyperimmunity and other recursion theoretic notions.

We show that the identity bounded Turing degrees of computably enumerable sets are not dense.

We prove a number of results in effective randomness, using methods in which Π⁰₁ classes play an essential role. The results proved include the fact that every PA Turing degree is the join of two random Turing degrees, and the existence of a minimal pair of LR degrees below the LR degree of the halting problem.

Despite regulatory reforms aimed at inhibiting aggressive financial reporting, earnings management persists and continues to concern practitioners, regulators, and standard setters. To provide insight into this practice and how to mitigate it, we conduct an experiment to examine the impact of two independent variables on CFOs’ discretionary expense accruals. One independent variable, incentive conflict, is manipulated at two levels —i.e., the presence or absence of a personal financial incentive that conflicts with a corporate financial incentive. The other independent variable is (...) CFOs’ earnings management ethics, measured as their assessment of the ethicalness of key earnings management motivations. We find that incentive conflict and EM-Ethics interact to determine CFOs’ discretionary accruals such that in the presence of incentive conflict, CFOs with low EM-Ethics tend to give into the personal incentive by booking higher expense accruals; and in the absence of an incentive conflict, CFOs with low EM-Ethics tend to give into the corporate incentive by booking lower expense accruals. We also find support for a mediated-moderation model in which CFOs’ level of EM-Ethics influences their moral disengagement tendencies which, in turn, differentially affect their discretionary accruals, depending on the presence or absence of incentive conflict. Theoretical and practical implications of these findings are discussed. (shrink)

Excerpt from The Eternal Order I believed in a personal God, who created the beav ens and earth and all contained therein; in a personal devil, who had once been an angel, but had become evil through an avaricious ambition; in a literal heaven, and hell; that at death one went to one or the other of those places, eternally. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is (...) a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

Recent history makes clear that the quantum leaps being made in technology are the leading edge of a groundswell of paradigm shifts taking place in science, politics, economics, social institutions, and the expression of cultural values. Indeed it is the simultaneity and interdependence of these changes occurring in every dimension of human experience and endeavor that makes the present so historically distinctive. The essays gathered here give voice to perspectives on the always improvised relationship between technology and cultural values from (...) Africa, the Americas, Asia, Australia, Europe, and the Pacific. Contributors: Syed Muhammad Naquib Al-Attas, Roger T. Ames,Yoko Arisaka, Carl Becker, Francesca Bray, James Buchanan, Arindam Chakrabarti, Frank W. Derringh, Rolf Elberfeld, Charles Ess, Andrew Feenberg, Susantha Goonatilake, H. Jiuan Heng, Peter Hershock, Thomas P. Kasulis, George Khushf, David Farrell Krell, Joel J. Kupperman, William R. LaFleur, Lois Ann Lorentzen, David Loy, Joseph Margolis, Hans-Georg Möller, Robert Cummings Neville, Peimin Ni, Monica Atieno Opole, Kuruvilla Pandikattu SJ, Helen Petrovsky, Ramon Sentmartí, Kristin Shrader-Frechette, Vasanthi Srinivasan, Marietta Stepaniants, Vyacheslav S. Stiopin, Henk ten Have, Paul B.Thompson, Mary Tiles, David B.Wong. (shrink)

The U.S. Food and Drug Administration's rationale for supporting the development and approval of BiDil for heart failure specifically in black patients was based on under-powered, post hoc subgroup analyses of two relatively old trials , which were further complicated by substantial covariate imbalances between racial groups. Indeed, the only statistically significant difference observed between black and white patients was found without any adjustment for potential confounders in samples that were unlikely to have been adequately randomized. Meanwhile, because the accepted (...) baseline therapy for heart failure has substantially improved since these trials took place, their results cannot be combined with data from the more recent trial amongst black patients alone. There is therefore little scientific evidence to support the approval of BiDil only for use in black patients, and the FDA's rationale fails to consider the ethical consequences of recognizing racial categories as valid markers of innate biological difference, and permitting the development of group-specific therapies that are subject to commercial incentives rather than scientific evidence or therapeutic imperatives. This paper reviews the limitations in the scientific evidence used to support the approval of BiDil only for use in black patients; calls for further analysis of the V-HeFT I and II data which might clarify whether responses to H-I vary by race; and evaluates the consequences of commercial incentives to develop racialized medicines. We recommend that the FDA revise the procedures they use to examine applications for race-based therapies to ensure that these are based on robust scientific claims and do not undermine the aims of the 1992 Revitalization Act. (shrink)

Researchers of advanced technologies are constantly seeking new ways of measuring and adapting to user performance. Appropriately adapting system feedback requires accurate assessments of user performance. Unfortunately, many assessment algorithms must be trained on and use pre‐prepared data sets or corpora to provide a sufficiently accurate portrayal of user knowledge and behavior. However, if the targeted content of the tutoring system changes depending on the situation, the assessment algorithms must be sufficiently independent to apply to untrained content. Such is the (...) case for Interactive Strategy Training for Active Reading and Thinking (iSTART), an intelligent tutoring system that assesses the cognitive complexity of strategy use while a reader self‐explains a text. iSTART is designed so that teachers and researchers may add their own (new) texts into the system. The current paper explores student self‐explanations from newly added texts (which iSTART had not been trained on) and focuses on evaluating the iSTART assessment algorithm by comparing it to human ratings of the students’ self‐explanations. (shrink)

This study reports the results of a survey of 405 high school students in a school district in the western United States. The data were used to determine why so many students take only the minimal science required for graduation. Key areas addressed included how science is taught; science literacy; science, technology, engineering and mathematics (STEM); science, technology, and society (STS); and who influences students to take science. Results were directed at how to motivate more students to continue science study (...) beyond the required courses and how to improve the prospect of more students choosing STEM majors in higher education. Key conclusions included that no new science courses are needed to increase enrollments, but existing courses need to be taught differently, specifically with more labs and activities that create more interest and relevance for students. Furthermore, students need more awareness of good reasons for taking science. Last, science instruction must improve. (shrink)

This study reopens the question of the nature of political commitment and its causes during a time that drastically altered the history of the 20th century, the 1920s and 1930s. Focused largely on a body of texts produced by Japanese female writer Miyamoto Yuriko who returned from a three-year long trip to the Soviet Union in late 1920s as a convinced communist, the study offers a comparison with communism renunciation writings produced by leftist Romanian French writer Panait Istrati, as well (...) as other communist and fellow travelers who experienced the same Soviet realities as Miyamoto but with opposite outcomes, such as French writer André Gide. What made those members of the intelligentsia so passionately embrace or renounce certain political ideologies that ultimately changed the face of modern history? (shrink)

This study reopens the question of the nature of political commitment and its causes during a time that drastically altered the history of the 20th century, the 1920s and 1930s. Focused largely on a body of texts produced by Japanese female writer Miyamoto Yuriko (1899-1951) who returned from a three-year long trip to the Soviet Union in late 1920s as a convinced communist, the study offers a comparison with communism renunciation writings produced by leftist Romanian French writer Panait Istrati (1894-1935), (...) as well as other communist and fellow travelers who experienced the same Soviet realities as Miyamoto but with opposite outcomes, such as French writer André Gide (1869-1951). What made those members of the intelligentsia so passionately embrace or renounce certain political ideologies that ultimately changed the face of modern history? (shrink)

Complementary and alternative medicine research presents unique problems for research ethics committees which must be considered in some detail. Applying conventional research techniques to CAM raises a number of issues which ethics committees may find challenging. CAM is widely available and this will have a substantial effect on any proposed research strategy as so many individuals will have pre-existing opinions about these treatments. Whilst many complementary therapies may eventually be ‘validated’ by appropriate clinical trial methodologies other research methods could be (...) more appropriate in the early stages of a research strategy, particularly in view of the widespread availability in both the public and private sectors. Safety, efficacy, cost-effectiveness and patient preference also need evaluation; and these cannot be adequately assessed through double blind randomised placebo controlled trials. If the research question is clear, then thoughtful and often innovative evaluative processes can be designed to answer the socially and clinically relevant issues posed by this area of medicine. There are a number of agencies and organizations available to offer advice to ethics committees in this newly emerging field of CAM research including CAM Strategy Research and Development, the Foundation for Integrated Health and the Research Council for Complementary Medicine. (shrink)